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NNMT plays a crucial role in the methylation of nicotinamide, affecting intracellular nicotinamide adenine dinucleotide (NAD+) metabolisma key cellular cofactor for redox reactions, DNA repair, and transcriptional regulation
It works by inhibiting an enzyme called NNMT (nicotinamide N-methyltransferase), which plays a role in slowing metabolism and increasing fat storage as we age
This supernutrient lowers the risk of anemia, enhances mood, and supports brain function
Most patients experience no discomfort
The downside is that it costs more, and there are potential side effects
NICE guidelines recommend hydroxocobalamin 1 mg intramuscularly three times weekly for 2 weeks (without neurological involvement) or on alternate days until no further improvement (with neurological symptoms)
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